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Institute of Dentistry

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Dr Noha Seoudi, BDS(Hons), LDSRCSEng, MDS, MFDS RCPS(Glasg), FRCPath, PhD

Noha

Clinical Lecturer

Email: n.seoudi@qmul.ac.uk
Telephone: +44 20 7882 6345
Room Number: Institute of Dentistry

Profile

Following her graduation with an honours degree in dentistry and achieving a Master's Degree in Oral Medicine, she completed a period of general dental training and became a Member of the Faculty of Dental Surgery, Royal College of Physicians and Surgeons of Glasgow. Later on, she was awarded one of the very few academic training posts in Clinical Oral Microbiology and became a Fellow of the Royal College of Pathologists by examination. Her PhD thesis was focused on the interrelationship between oral microbiome and host immune response in patients with Behçet's Disease.

Dr Seoudi has clinical, research and teaching responsibilities. Her main clinical areas of interest are: Clinical Oral Microbiology, Infection and Immune in relation to oral health, and Infection Prevention and Control. Her main research area of interest is the interrelationship between host immune response and oral microbiome in health and disease. She is proud to be a holder of the Young Investigator Award (International Conference on Behçet's Disease, Japan, 2012).  She considers teaching one of the most rewarding experiences in her career.  She enjoys teaching a wide range of students from different cultural backgrounds and different learning needs and thrives in the challenge of tailoring her teaching style to benefit all students.

Research

Research Interests:

Dr Seoudi's current research interests are focused in the following areas:

The Microbiome analysis in human health and disease: She analysed the Oral Microbiome of Behçet's Disease patients using MALDI-TOF analysis and envisaged that the discrepancy in the oral microbiome of Behçet's Disease patients can be targeted in the future by probiotics to restore the balance of the oral microbial community, leading to better oral health which in turn will potentially enable a better control of the Behçet's Disease immune response.

The interrelationship between host immune response and oral microbiome in human health and disease: Noha previously highlighted that the higher level of expression of some of the unusual splice variants of Toll Like Receptor (TLR) 2 and TLR4 mRNA in the oral mucosa of Behçet's Disease patients, explains the functional defect in TLR1/2 heterodimer and TLR4 in this patients' group. This in turn can be expected to cause a failure in the adaptive immune response modulation an increase susceptibility to oral infections.

The effect of Oral Health on the Quality of Life (QoL) of immune related diseases: She previously demonstrated that Behçet's Disease is a devastating chronic disease affecting patients' QoL and that the Oral Health Status of these patients has a negative effect on their QoL. She wishes to investigate the effect of the oral health status on the QoL in relation to other immune related diseases.

Evaluating the accuracy of new laboratory tests: She previously investigated the accuracy of the Rapid Molecular Detection of Tuberculosis and Rifampicin Drug Resistance and evaluated of the importance and accuracy of PCR in Medical Microbiology Service.

Auditing the practice in the infection prevention and control field: She analysed the incidence of needle-stick injuries and recommended a remedial bundle. She audited the infection prevention and control strategy in the wards of hematopoietic stem cell transplant recipients at St Bartholomew's Hospital which successfully reduced the incidence of Clostridium difficile infection by 64%. Additionally, one of Noha's audits highlighted the strategy used in St Bartholomew's Hospital to control the rate of vancomycin- resistant entrococcal bloodstream infection in patients with hematological malignancy.

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