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Institute of Dentistry

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Dr Nikos Mardas, Dipl DS, MS, PhD

Nikos

Specialist in Periodontics, Senior Clinical Lecturer & Honorary Consultant

Profile

Dr Nikos Mardas qualified in Dentistry from Athens University in 1992; He completed his 3-year specialist training and MS degree in Periodontology in 1997 at the Royal Dental College, University of Aarhus, Denmark. He was awarded a PhD degree in 2005 from the same University.

During the period 2005-2015 he was a Senior Lecturer / Honorary Specialist and M.Clin.Dent program co-ordinator in Periodontology Unit, at UCL, Eastman Dental Institute. In July 2015, he was appointed Senior Clinical Lecturer & Honorary Consultant in the Centre for Adult Oral Health, Barts & The London School of Dentistry, Queen Mary University of London. Dr Mardas is also consultant Periodontist and implant surgeon in private practice.
He has published several papers in national and international peer-reviewed journals in the field of periodontal, bone regeneration and implant dentistry and he is editorial board member in Clinical oral Implant Research and regular reviewer for many international and national journals. He has participated as a reviewer in consensus meetings of EAO, EFP and EADE and has extensively lectured nationally and internationally. In 2011 he was awarded the Basic Research Prize, of the European Association for Osseointegration. In March 2015 was appointed Education Delegate for the UK & Ireland ITI section.
Dr. Mardas has more than 18 years of private practice and university / hospital based clinical experience in treatment of periodontal diseases including conventional and regenerative periodontal surgery, periodontal plastic surgery, alveolar bone augmentation procedures and dental implants alone or in combination with bone grafting procedures.

Research

Research Interests:

His main research interests are in the area of periodontal, bone and gingival tissue regeneration and wound healing, utilising various biomaterials. He has also a special interest on the outcome of the above mentioned treatment principles in specific systemic conditions like osteoporosis. In the last 10 years, he has been actively involved in several research projects, including in vitro biomaterial testing and development, preclinical - animal experimental projects and randomised clinical trials, evaluating the effectiveness of new regenerative materials for bone and periodontal regeneration, as well as dental implant related treatment protocols.

His current and future research is focusing on:

• The evaluation of current bone and periodontal tissue regeneration and implant protocols in healthy or compromised healing conditions by means of preclinical and clinical studies.
• The development of tissue regeneration protocols based on the combination of novel biomaterials / scaffolds for growth factor, cell or chemotherapeutics delivery
• The evaluation of different types of periodontal surgery in terms of clinical, microbiological and patient based outcome
•  The creation of a sound scientific link between in-vitro studies, pre-clinical animal experiments and initial clinical trials for the treatment of peri-implantitis
• The systematic evaluation and analysis of the literature in the field of periodontal and bone regeneration and implant outcomes

Publications

Scientific articles

Guided Tissue Regeneration in Infrabony Defects with Resorbable Membranes.  Sculean A, Chiantella G, Mardas N, Herrero F, Karring T. Parodontologie 1996; 3:223-234.

Guided Tissue Regeneration. Chiantella G, Sculean A, Herrero F, Mardas N. Dental Cadmos 1997; 2: 46-53.

Deproteinized bovine bone used as an adjunct to guided bone augmentation: an experimental study in the rat. Stavropoulos A, Kostopoulos L, Mardas N,  Karring T. Clinical Implant Dentistry Related Research 2001 ; 3(3) :156-165.

Bone and suture regeneration in calvarial defects by e-PTFE-membranes and demineralised bone matrix and the impact on calvarial growth: an experimental study in the rat. Mardas N, Kostopoulos L, Karring T.  Journal Craniofacial Surgery 2002; 13(3):453-462.

Osteogenesis by guided tissue regeneration and demineralised bone matrix. Mardas N, Kostopoulos L, Stavropoulos A, Karring T. Journal Clinical Periodontology 2003; 30(3):176-183.

Influence of demineralised bone matrix‘s embryonic origin on bone formation: an experimental study in rats. Stavropoulos A, Kostopoulos L, Mardas N,  Karring T. Clinical Implant Dentistry Related Research 2003 ; 5(3) :184-192.

Gentamicin used as an adjunct to GTR. Stavropoulos A, Kostopoulos L, Mardas N, Karring T. Journal Clinical Periodontology 2003; 30(5):455462.

Denaturation of demineralised bone matrix significantly reduces bone formation by guided tissue regeneration. Mardas N, Kostopoulos L, Stavropoulos A,  Karring T. Clinical Oral Implants Research 2003 ; 14(6) :804-811.

Evaluation of a cell-permeable barrier for guided tissue regeneration combined with demineralised bone matrix. Mardas N, Kostopoulos L, Stavropoulos A,  Karring T. Clinical Oral Implants Research 2003 ; 14(6) :812-818.

Smoking affects the outcome of guided tissue regeneration with bioresorbable membranes: a retrospective analysis of intrabony defects. Stavropoulos A, Mardas N, and Karring T. Journal Clinical Periodontology 2004; 31(11): 945-950.

The cooperation between the orthodontist and the Periodontist in orthodontic treatment of patients with periodontal problems. Sakellariou A, Pettas A, Mardas N.  Analecta Periodontologica 2004.

Knogleregeneration med styret vaevsrgeneration og demineraliseret knoglematriks. Mardas N Tandlaegebladet 2005; 11: 896.

Guided bone regeneration in bone defects associated with dental implants. (Part I) Mardas N. Private Dentistry 2006 (11)2: 24.

Guided bone regeneration in bone defects associated with dental implants. (Part II) Mardas N. Private Dentistry 2006 (11)2: 18

Anorganic bovine-derived hydroxyapatite matrix coupled with a synthetic cell-binding peptide (PepGen P-15) for bone regeneration. An experimental study in rats. Mardas N., Stavropoulos A. And Karring T.  Clinical Oral Implants Research 2008 (19) 1010–1015.

Clinical outcomes of implants following lateral bone augmentation: systematic assessment of available options (barrier membranes, bone grafts, split osteotomy). Donos N, Mardas N, Chadha V. Journal Clinical Periodontology 2008; 35 (8 Suppl):173-202.

Advances in bone augmentation to enable dental implant placement: Consensus Report of the Sixth European Workshop on Periodontology. Tonetti MS, Hämmerle CH; Abrahamsson I, Becker J, Blanco J, Botticelli D, Donos N, Giannobile W, Jung R, Mardas N, Neukam E, Parlar A, Pjetursson B, Rocchietta I, Simion M, Stavropoulos A, Thoma D, European Workshop on Periodontology Group C. Journal Clinical Periodontology 2008; 35 (8 Suppl):168-72.

An outline of competencies and the appropriate post-graduate educational pathways in implant dentistry. Donos, N., Mardas N., Buser D. European Journal of Dental Education 2009 13(1 Suppl): 44-54

Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomised, controlled clinical trial. Mardas N, Chadha V, Donos N. Clinical Oral Implants Research 2010; 21: 688–698.

Effect of immediate or delayed loading following immediate placement of implants with a modified surface. An experimental study in minipigs.  A. Liñares, N. Mardas N. Dard, N. Donos. Clinical Oral Implants Research 2011;22(1):38-46.

The effect of SLActive surface in guided bone formation in osteoporotic like conditions. Mardas N, Schwarz F, Petrie A,  Hakimi AR, Donos N  Clinical Oral Implants  2011; 22 : 406–415.

Radiographic alveolar bone changes following ridge preservation with two different biomaterials. Mardas N, D’Aiuto F, Mezzomo L, Arzoumanidi M, Donos N. Clinical Oral Implants Research 2011; 22: 416–423.

The use of human hypertrophic chondrocytes extracellular matrix for the treatment of critical-size defects in rats. Donos N, Graziani F,  Mardas N, Kostopoulos L.  Clinical Oral Implants Research 2011; 22(12):1346-53

Cell attachment and response to photo - cured, degradable bone adhesives containing tricalcium phosphate and purmorphamine. Gellynck K, Ensanya A. Abou Neel, HaoYing Li, Mardas N, Donos N, Buxton P, Young A. Acta Biomaterialia 2011; 7(6):2672-7.

Alveolar ridge preservation after dental extraction and before implant placement: A literature review Mezzomo L, Sadami Shinkai R,  Mardas N, Donos N. Revista Odonto Ciência (Journal of Dental Science)2011; 26(1):77-83.

The Guided Bone Regeneration principle and its clinical applications. Zambon, R., Mardas, N., Donos, N. Implant Dentistry Today 2011; 9:5-11

Alveolar ridge preservation and extraction wound healing revisited. Mardas N, Arzoumanidi M, Donos N. Periodontoliga Analecta 2011.

Hierarchical decisions on teeth versus implants in the periodontitis susceptible patient: the modern dilemma. Donos N, Laurel L, Mardas N. Periodontology 2000. 2012; 59(1):89-110.

Regenerative wound healing in an acute degree III furcation involvement model. Mardas, N., Kraehenmann, M.A., Dard, M., Alves, A., Donos, N Quintessence International 2012; 43(5):e48-59.

The effect of loading in dehiscence-type defects following GBR. Zambon R, Mardas N, Horvath A,  Dard M,  Donos N Clinical Oral Implants Research 2012; 23(5):591-601.

Clinical and aesthetic outcomes of single tooth implants in the anterior maxilla. Furtze D, Byrne A, Donos N, Mardas N. Quintessence International 2012;43(2):127-34.

Systematic review of the association between genetic predisposition and dental implant  biological complications Dereka, X., Mardas, N.,  Chin, C.,  Petrie, A,  Donos, N. Clinical Oral Implants Research 2012; 23(7):775-88

Radiographic and clinical outcomes of implants placed in ridge preserved sites: 12-month post-loading follow-up. Patel K, Mardas N, Donos N. Clinical Oral Implants Research 2011; 22: 416–423.  

Alveolar ridge preservation. A systematic review. Horvath A, Mardas N, Mezzomo L, Needleman I, Donos N Clinical Oral Investigation 2013; 17:341-363

A systematic review on the critical size defect model. Vajgel, A., Mardas, N., Farias, B. C., Petrie, A., Cimões, R., & Donos, N. (2013). Clinical Oral Implants Research. 25(8): 879-93

Experimental Model for Bone Regeneration in Oral and Cranio-Maxillo-Facial Surgery. Mardas, N., Dereka, X., Donos, N., & Dard, M. (2014). J Investigative Surgery 27(1):32-49

Stage-two surgery using collagen soft tissue grafts: Clinical cases and ultrastructural analysis. Fischer KR, Fickl S, Mardas N, Bozec L, Donos N. (2014) Quintessence International 45(10): 853-60.

Panoramic morphometric indices for detecting reduced bone mineral density. A systematic review and meta-analysis. E. Calciolari, N. Donos, JC. Park A. Petrie & N. Mardas Journal of Dental Research 2014 Nov 3. pii: 0022034514554949.

Horizontal Ridge augmentation. Donos N & Mardas N in Osteology Guidelines for Oral and Maxillofacial Augmentation Edits: Klaus Lang, William Gianobille, Mauricio Tonetti

A systematic review on the correlation between skeletal and jawbone mineral density in osteoporotic subjects. Calciolari E, Donos N, Park JC, Petrie A & Mardas N. Clinical Oral Implants Research 2015 Apr 12. doi: 10.1111/clr.12597

Experimental models for guided bone regeneration in healthy and medically compromised conditions. Donos N, Dereka X & Mardas N. Periodontology 2000. 2015: 68(1):99-121.

Does ridge preservation following tooth extraction improve implant treatment outcomes: a systematic review. Group 4: Therapeutic concepts & methods. Mardas N, Trullenque-Eriksson A, MacBeth N, Petrie A, Donos N. Clinical Oral Implants Research 2015 26 (Suppl. 11), 2015, 180–201. doi: 10.1111/clr.12639

Therapeutic concepts and methods for improving dental implant outcomes. Summary and consensus statements. The 4th EAO Consensus Conference 2015. Sanz M, Donos N, Alcoforado G, Balmer M, Gurzawska K, Mardas N, Millinkhovic I, Nisand D, Rocchietta I, Stavropoulos A, Thoma DS, Torsello F.  Clinical Oral Implants Research 26 (s11), 2015, 202–206 doi: 10.1111/clr.12674.

A systematic review of implant outcomes in treated periodontitis patients. Sousa V, Mardas N, Farias B, Petrie A, Needleman I, Spratt D, Donos N. Clinical Oral Implants Research 2015 Sep 18. doi: 10.1111/clr.12684.

Sousa V, Mardas N, Spratt D, Boniface D, Dard M, Donos N. Experimental models for contamination of titanium surfaces and disinfection protocols. Clinical Oral Implants Research. 2016 Feb 10. doi: 10.1111/clr.12735.  

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