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Institute of Dentistry

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Dr Anwar Tappuni, BDS, LDSRCS, PhD, MRACDS (OM), FHEA

Anwar

Reader in Oral Medicine/Honorary Consultant and Academic Lead for Oral Medicine

Email: a.r.tappuni@qmul.ac.uk
Telephone: +44 20 7882 8655
Room Number: Institute of Dentistry

Profile

Anwar R Tappuni is the Academic Lead for Oral Medicine at the Institute of Dentistry, Barts and The London School of Medicine and Dentistry. She is the founder and Director of the QMUL Master in Clinical Dentistry in Oral Medicine, the first programme of its kind in the UK.  She is a Member of the QMUL Senate, Research Ethical Committee and the School of Medicine and Dentistry Professional Capabilities and Fitness to Practice Boards. Anwar has several current international and national roles including Council Member and Divisional President at the International Association for Dental Research, Founder and Editor-in-chief of the Journal of Oral and Dental Research, Member of the Editorial Board of the highest impact factor dental journal; Journal of Dental Research, Member of the Specialty Advisory Board for Oral Medicine at the Royal College of Surgeons of Edinburgh, Member of the Royal College of Surgeons of England Examination Board for Diploma in Special Care Dentistry, Medical Council Member and Trustee for the British Sjögren’s Syndrome Association, Chair of the BMA/BDA Refugee Doctors and Dentists Liaison Group, Member of the BDA Central Committee for Dental Academic. She is a reviewer for the Medical Research Council and for several scientific journals in the field. She leads a multidisciplinary research clinic for Sjögren’s syndrome and is a member of a group developing the National Guidelines for the clinical management of Sjögren’s syndrome. Anwar co-chaired the International Steering Committee and the meeting of the 7th World Workshop for Oral Health and Disease in AIDS in 2014 in Hyderabad, India. She is a guest editor of a Supplement of Oral Diseases for the Conference Proceedings and the first author of the Research Agenda for Oral HIV/AIDS paper. Anwar is supervising and supporting several postdoctoral and PhD projects in her fields of research interest; oral manifestations of HIV and Sjögren’s syndrome. She has developed and published a clinical tool for assessing severity of oral ulcerative disease, which has been adopted for use in several clinical units and employed in clinical trials.  Anwar has been awarded the BDA Roll of Distinction for outstanding service to UK dentistry.

Research

Research Interests:

Oral Medicine Lead for Multidisciplinary Research Clinic for Sjogren’s Syndrome. Current research activities in this clinic include:

  • The prevalence of loss of taste and smell in dry mouth patients.
  • The effect of Sjogren’s syndrome on the sexual function of female patients.
  • The multidimensional impact of Sjogren’s syndrome on the physical and mental health of patients.
  • Several laboratory-based projects investigating the aetiology, pathogenesis and progression of Sjogren’s syndrome.

Other research interests

Clinical trials to evaluate efficacy of different therapies in recurrent oral ulceration and to investigate the serum and salivary levels of inflammatory markers and their relation to the severity of the oral ulceration.

Global inequalities in oral health and disease in HIV/AIDS. ww7india.com

Publications

Kumarasamy N, Ranganathan K, Tappuni AR, Challacombe SJ.  Suniti Solomon, Founder-Director Y.R. Gaitonde Centre for AIDS Research and Education. Oral Diseases 2016: Early view online publication

Challacombe SJ, Tappuni AR, Ranganathan K, Robinson PG, Williams DM, Johnson NW. Hyderabad declaration 2014  Oral Diseases 2016: Early view online publication

Astorri E, Sutcliffe N, Richards PS, Suchak K, Pitzalis C, Bombardieri M, Tappuni AR. Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms. Journal of Oral Pathology and Medicine. Published online 14 December 2015.

Challacombe SJ, Alsahaf S, Tappuni AR. Recurrent Aphthous Stomatitis: Towards Evidence-Based Treatment. Current Oral Health Reports 2015; 2 (3):158-167

Vartoukian SR, Tilakaratne W, Seoudi N, Bergmeier L, Tappuni AR, Fortune F. Dysregulation of the SOCS3-STAT3 pathway in the aetio-pathogenesis of Sjögren’s syndrome. Clinical and Experimental Immunology. 2014; 177, (3) 618-629.

Croia C, Astorri E, Murray-Brown W, Willis A, Brokstad KA, Sutcliffe N, Piper K, Jonsson R, Tappuni AR, Pitzalis C, Bombardieri M. Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome. Arthritis Rheumatol. 2014; 66: (9) 2545-2557.

Lakhani S, Barnett S, Tappuni AR et al. Recurrent lip swelling: a diagnostic challenge. British Medical Journal. Case Rep 2014. 10.1136/bcr-2013-203018

Tappuni AR and Tilakaratne WM, Oral Manifestations of Systemic Disease. In Oral Medicine and Pathology: A Guide to Diagnosis and Management. 563 pages. 2014. Jaypee Brothers Publishers. First Edition.

Tappuni AR, Kovacevic T, Shirlaw PJ, Challacombe SJ. Clinical assessment of disease severity in recurrent aphthous stomatitis. Journal of Oral Pathology and Medicine. 2013; 42: (8) 635-641.

Tappuni AR, Tbakhi A, Sharquie KE, Hayani RK, Al-Kaisi A, Lafi A, Al-Araj A. A Comparative Study of the Genetics of Behcet's Disease in Iraq. Med Confl Surviv, 2013; 29(1): 57-68.

Tappuni AR, Kovacevic T, Shirlaw, PJ, Challacombe SJ. Clinical Assessment of Disease Severity in Recurrent Aphthous Stomatitis. Journal of Oral Pathology and Medicine. 2013; 42(8): 635-41.

Ramirez-Amador V, Nittayananta W, Magalhães M, Flint SR, Peters BS, Tappuni AR. Clinical Markers of Immunodeficiency and Mechanism of Immune Reconstitution Inflammatory Syndrome and Highly Active Antiretroviral Therapy. Adv Dent Res, 2011; 23(1): 165-171.

Tappuni AR. Immune Reconstitution Inflammatory Syndrome. Ad Dent Res: 2011; 23 (1): 90-96.

Javed F, Correa FO, Chotai M, Tappuni AR, Almas K. Systemic Conditions Associated with Areca Nut Usage: A literature review. Scand J Public Health, 2010; 38 (8): 838-844.

Papagatsia Z, Jones J, Morgan P, Tappuni A. Oral Kaposi sarcoma: a case of immune reconstitution inflammatory syndrome. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2009; 108(1): 70-75.

Tappuni AR. A lump on the gingiva. In EW Odell (Ed), Clinical problem solving in dentistry. Churchill Livingstone. First edition 2000 and second edition 2009. 288 pages.

Naglik JR, Moyes D, Makwana J, Kanzaria P, Tsichlaki E, Weindl G, Tappuni AR, Rodgers CA, Woodman AJ, Challacombe SJ, Schaller M, Hube B. Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology, 2008; 154: 3266-80.

Papagatsia Z, Tappuni A, Watson R J, Cook T F. Single wavelength micro-endoscopy in non-surgical vascular lesion diagnosis & characterization. Journal of Microscopy, 2008; 230(2): 203-11.

Moutasim K, Tappuni AR., Current concepts in the pathogenesis and management of oral mucositis as a complication of cancer therapy. Journal of Disability and Oral Health, 2008; 9 (1): 17-26.

Escudier M, Ahmed N, Shirlaw P, Setterfield J, Tappuni A, Black M, Challacombe SJ.  A Novel Scoring System for Mucosal Disease: Application to Oral Lichen planus. British Journal of Dermatology, 2007; 157 (4): 765-770.

Chiandussi S, Tappuni AR, Watson TF, White A, Escudier M, Sanderson JD, Challacombe SJ. Assessment of Morphological Changes of the Lips in Patients with Orofacial Granulomatosis: A New Technique Using Lip Impressions. Oral Diseases, 2007; 13 (1): 93–98.

Tappuni AR. Other Dental and Oral Problems. In S Rankin Manual for Oral Health. 2007, 100 pages.

Flint SR, Tappuni A, Leigh J, Schmidt-Westhausen AM, MacPhail L. Markers of Immunodeficiency and Mechanisms of HAART Therapy on Oral Lesions. Adv Dent Res, 2006; 19: 146-151.

Tappuni AR, Kovacevic T, Shirlaw PJ, Challacombe SJ. Clinical Assessment of Disease Severity in Recurrent Aphthous Stomatitis. Oral Biosci Med, 2005; 2: 5-13.

Flint S, Glick M, Patton L, Tappuni A, Shirlaw P, Robinson P. Consensus guidelines on quantifying HIV-related oral mucosal disease. Oral Diseases 8 Suppl, 2002; 2: 115-9.

Tappuni AR, Fleming GJ. The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: a UK study. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 2001; 92 (6): 623-8.

Chaudhry SI, Tappuni AR, Challacombe SJ. Multiple maxillary and mandibular exostoses associated with multiple dermatofibromas: a case report. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics, 2000; 89 (3): 319-22.

Makarova N, Yurin O, Pokrovsky V, Tappuni AR. Infections in hospitalised Russian children with AIDS. Oral Diseases 3 Suppl, 1997; 1: S119-21.

Tappuni AR, Challacombe SJ. A comparison of salivary immunoglobulin A (IgA) and IgA subclass concentrations in predentate and dentate children and adults. Oral Microbiology & Immunology, 1994; 9 (3): 142-5.

Tappuni AR, Challacombe SJ. Distribution and isolation frequency of eight streptococcal species in saliva from predentate and dentate children and adults. Journal of Dental Research, 1993; 72 (1): 31-6.

Published abstracts 2010-2015


Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Bobardieri M. Next-Generation sequencing demonstrates dynamic recirculation of B cell clones in ectopic lymphoid structures of Sjögren's Syndrome. Annals of the Rheumatic Diseases 2015; 74 (Suppl 2), 425-426

Astorri E, Croia C, Picarelli G, Sutcliffe N, Tappuni A, Bombardieri M. Routine investigations for circulating IgG4 and/or IgG4+ salivary gland histopathology fail to reveal undiagnosed cases of IgG4 related disease in sicca patients not fulfilling the diagnosis of Sjögren’s syndrome.  Scandinavian Journal of Immunology 2015; 81 (5), 341-341

Amin K, Willis A, Plowman N, Jawad A, Bombardieri M, Tappuni A, A case of an unusual palatal lymphoma. International Journal of Oral and Maxillofacial Surgery. 2015; 44: e186

Murray-Brown W, Carlotti E, Floyd J, Sutcliffe N, Tappuni A, Vartoukian S, Bombardieri M. Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjogren's Syndrome. Scandinavian Journal of Immunology. 2015; 81:401-402.  

Astorri E, Croia C, Picarelli G et al. (2015) . Routine Investigations for Circulating IgG4 and/or IgG4+Salivary Gland Histopathology Fail to Reveal Undiagnosed Cases of IgG4 Related Disease in Sicca Patients not Fulfilling the Diagnosis of Sjogren's Syndrome. SCANDINAVIAN JOURNAL OF IMMUNOLOGY. vol. 81, 341-341

Astorri E, Tappuni A, Sutcliffe N, Richards P, Pitzalis C, Bombardieri M.  A Negative High-resolution Salivary Gland Ultrasound is Highly Predictive of Negative Labial Gland Biopsy in Patients with Sicca Symptoms. Annals of the Rheumatic Diseases. 2014; 73, 179-179.

Croia C, Serafini B, Tappuni A, Aloisi F, Sutcliffe N, Pitzalis C, Bombardieri M. Ectopic Lymphoid Structures Support Epstein-Barr Virus Persistence and Autoreactive Plasma Cell Infection in Sjogren’s Syndrome Salivary Glands.  EULAR; Annals of the Rheumatic Diseases 2013; 72, 462-462.

Murray-Brown W, Croia C, Sutcliffe N, Tappuni A, Pitzalis C, Bombardieri M. Lesional Intereukin-21 Expression Correlates with Functional Germinal Center Formation and T Follicular Helper Cell Infiltration in the Salivary Glands of Sjögren’s Syndrome. Arthritis and Rheumatism. 2013; 65:S634-S634.

Astorri E, Bombardieri M, Sutcliffe N, Mohammed A, Willis A, Piper K, Richards P, Tappuni AR. Efficacy Of High-Resolution Ultrasound Compared with Labial Gland Biopsy in the Diagnosis of Sjögren’s Syndrome. British Society for Oral Medicine; 2013.

Murray-Brown W, Croia C, Sutcliffe N, Anwar Tappuni  et al. Lesional IL-21 Expression Correlates With Functional Germinal Center Formation And T Follicular Helper Cell Infiltration In The Salivary Glands of Sjögren’s Syndrome. Immunology. 2012; 137:491-491.

Vartoukian SR, Tilakaratne WM, Bombardieri M, Seoudi N, Sutcliffe N, Piper K, Fortune F, Tappuni AR. SOCS3 Dysregulation In Primary Sjögren’s Syndrome. International Association Dental Research. 2012.

Alsahaf S, Tappuni AR, Challacombe SJ. Management of Recurrent Aphthous Stomatitis with Colchicine and Betnesol Mouthwash. Oral Diseases. 2012; 18: 30-30.

Alsahaf S, Tappuni AR, Challacombe SJ. Efficacy of Colchicine and Betamethasone Mouthwash in Recurrent Aphthous Stomatitis. Oral Diseases. 2010; 16: 516–572.

Alsahaf S, Tappuni AR, McParland H, Cook RJ, et al. The Efficacy of Colchicine with and without Betnesol Mouthwash in the Management of Recurrent Aphthous Stomatitis. British Society for Oral Medicine. 2010.

Abdelghani A, Tappuni A, Begum S et al. An unusual location for a salivary gland stone. Oral Diseases. 2010; 16: 564-564.

Challacombe SJ, Tappuni AR, McParland H et al.  Assessment of Disease Severity and Treatment Responses in Oral Mucosal Diseases Oral Diseases. 2010; 16: 539-540.

Alsahaf S, Tappuni A, McParland H et al. Evaluation Of The Efficacy Of Colchicine With And Without Betnesol Mouthwash In Management of Recurrent Aphthous Stomatitis. Oral Diseases. 2010; 16: 546-546.

Begum SS, Tappuni AI, Abdelghani A et al.  Linear Naevus Sebaceous Syndrome. Oral Diseases. 2010; 16: 563-563.

Alsahaf S, Cook RJ, Matharu H, Tappuni A et al.  Oral Disease Severity Scores and Treatment in Patients with Recurrent Ulcers. Oral Diseases. 2010; 16: 546-546.

PhD Supervision

She is currently supervising two PhD projects; one investigating smell, taste and sexual function in Sjögren’s patients and the other is a double-blind placebo controlled trial of the efficacy of a dental varnish in treating root caries in dry mouth patients. She is also a co-investigator in two industry-funded clinical trials for treatment modalities for Sjögren’s Syndrome. PhD opportunities are available in the subjects of Sjögren’s syndrome and Oral manifestations of HIV.

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